Dalton Mass Spectrometry Group

	Currently, our laboratory disposes of four mass spectrometers, described in further detail below
			Waters Synapt HDMS (ESI/MALDI-QTOF)
			The SYNAPT™ HDMS™ System is a flexible research platform providing: • Triwave™ Technology: Provides access to the unique benefits of ion mobility spectrometry (IMS), conformational studies, reducing sample complexity, and enhanced fragmentation • Time aligned parallel (TAP) fragmentation: Provides comprehensive structural (MS/MS/MS) information in a single experiment • High duty cycle (HDC) mode: Enables significant sensitivity enhancements over a wide m/z range • DriftScope™ Software mobility environment: For interactive visualization and manipulation of multidimensional data • Exact mass: 2 ppm RMS • High resolution: Over 17,500 FWHM • High sensitivity: Class-leading sensitivity, which features • Enhanced duty cycle (EDC) capability for maximum duty cycle over specified m/z range • Dynamic range: > 4 orders of linearity • UPLC Ready Acquisition Rates: Up to 10 spectra/sec • Precursor ion selection: 4, 8, and 32KDa quadrupole options for MS/MS analysis • UPLC/MSE: High-definition metabolite and protein profiling • MassLynx™ Informatics: i-FIT, MetaboLynx™, MassFRAGMENT™, MarkerLynx™, and ProteinLynx™ Global SERVER

			Waters Xevo Q-TOF (ESI-QTOF)
			To provide the ultimate system solution, Xevo QTof MS features: • IntelliStart™ Technology for simplified set-up and performance monitoring. • Designed with ACQUITY UPLC® Technology in mind to leverage the benefits of the highest chromatographic resolution, speed, and sensitivity. • Outstanding sensitivity and selectivity to deliver high-quality, reproducible exact mass measured data routinely. • MassLynx™ Informatics to deliver simple and rapid compound identification and interpretation. This allows you to make intelligent business decisions faster.

			Waters Quattro Micro API (ESI-QqQ)
			Developed for routine HPLC/MS/MS quantitative applications and qualitative screening, the Quattro Micro™ API is an affordable, high quality tandem quadrupole MS delivering superior levels of sensitivity, selectivity, robustness, speed, and accuracy. Features: • Accurate, reproducible chromatographic peak area measurement • Robust ZSpray™ atmospheric pressure ionization interface • Versatile range of ionization options • Multimode capability in a single run • Automated instrument optimization and quantitative method development tools • Dedicated application managers for your specialized analytical requirements • Small footprint that sits easily on your laboratory benchtop

			Waters GCT Premier (GC-TOF)
			The GCT Premier™ benchtop orthogonal acceleration time-of-flight (oa-TOF) mass spectrometer delivers high sensitivity, resolution, and exact mass measurements for GC/MS applications. Its fast data acquisition rates and automated workflow features match the requirements for MS detection when coupled to high-resolution capillary GC. A variety of GC inlet, ion source and software options makes the GCT Premier a versatile choice for a range of analytical challenges, from identifying contaminants in food and environmental samples to metabolomic studies. Features: • High MS resolution for the selectivity needed to separate analyte spectra from isobaric interferences and background chemical noise • High sensitivity for achieving very low detection limits • High linear dynamic range, which allows experiments to be carried out across a range of concentration levels • Exact mass MS measurements, which give elemental composition information that can be used to identify analyte compounds; you can obtain exact mass measurements on both molecular and fragment ions, simplifying the process of spectrum interpretation • Versatile ionization options that apply to a range of compound classes, including support for both direct insertion probe and GC analyses • Versatile software options for a variety of applications